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A-304121 CAS: 360551-71-9

Category: Inhibitors
Product Name: A-304121
Cat No: I000188
CAS No: 360551-71-9
Synonyms: A-304121;(2R)-2-amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-one
Molecular Formula: C20H29N3O3
Molecular Weight: 359.47
SMILES: C[C@@H](N)C(N1CCN(CCCOC2=CC=C(C(C3CC3)=O)C=C2)CC1)=O
InChI: InChI=1S/C20H29N3O3/c1-15(21)20(25)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)19(24)16-3-4-16/h5-8,15-16H,2-4,9-14,21H2,1H3/t15-/m1/s1
InChIKey: KPXVCGPCRXEDLT-OAHLLOKOSA-N
Solubility: Soluble in DMSO
Target: None
CAS 360551-71-9,A-304121
  • Description

A-304121 is a histamine H(3) receptor.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121. Pan JB, Yao BB, Miller TR, Kroeger PE, Bennani YL, Komater VA, Esbenshade TA, Hancock AA, Decker MW, Fox GB.Life Sci. 2006 Aug 29;79(14):1366-79. Epub 2006 Apr 26. PMID: 16730751
2:Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):887-96. Epub 2003 Feb 20. PMID: 12606603 Free Article
3:Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization. Fox GB, Pan JB, Radek RJ, Lewis AM, Bitner RS, Esbenshade TA, Faghih R, Bennani YL, Williams M, Yao BB, Decker MW, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):897-908. Epub 2003 Feb 20. PMID: 12606600 Free Article


price inquiry for CAS:360551-71-9, Product:A-304121