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Trelagliptin succinate CAS: 1029877-94-8

Category: Inhibitors
Product Name: Trelagliptin succinate
Cat No: I000181
CAS No: 1029877-94-8
Synonyms: 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile;butanedioic acid
Molecular Formula: C22H26FN5O6
Molecular Weight: 475.47
SMILES: CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N.C(CC(=O)O)C(=O)O
Solubility: 10 mM in DMSO
Target: DPP-4
Storage: Store at -20°C
CAS 1029877-94-8,Trelagliptin succinate
  • Description

Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
IC50 value:
Target: DPP4
Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance.

  • References


[1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus
[2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus
[3]. Long-term Study of SYR-472
[4]. SYR-472 Open-label Study


price inquiry for CAS:1029877-94-8, Product:Trelagliptin succinate