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Pexidartinib CAS: 1029044-16-3

Category: Inhibitors
Product Name: Pexidartinib
Cat No: I000179
CAS No: 1029044-16-3
Synonyms: 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
Molecular Formula: C20H15ClF3N5
Molecular Weight: 417.8
SMILES: ClC1=CC2=C(N=C1)NC=C2CC3=CN=C(NCC4=CN=C(C(F)(F)F)C=C4)C=C3
InChI: InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChIKey: JGWRKYUXBBNENE-UHFFFAOYSA-N
Solubility: DMSO: ≥ 30 mg/mL
Target: CSF-1R
IC50: 28/16 nM(Fms/Kit)
Storage: Store at -20°C
CAS 1029044-16-3,Pexidartinib
  • Description

Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
IC50 value: 28/16 nM(Fms/Kit)
Target: multikinase inhibitor
Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.

  • Spec

Appearance:Yellow solid powder
Purity: > 98%

  • References


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