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Mulberroside A CAS: 102841-42-9

Category: Inhibitors
Product Name: Mulberroside A
Cat No: I000177
CAS No: 102841-42-9
Molecular Formula: C26H32O14
Molecular Weight: 568.52
Solubility: DMSO: 40 mg/mL
IC50: 1.29 μmol/L (inhibition of the monophenolase activity); KI value: 0.385 μmol/L (the inhibition constant of the effectors on tyrosinase); KIS value: 0.177 μmol/L (the inhibition constant of the enzyme-substrate complex) [3]
CAS 102841-42-9,Mulberroside A
  • Description

Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics.
IC50 value: 1.29 μmol/L (inhibition of the monophenolase activity); KI value: 0.385 μmol/L (the inhibition constant of the effectors on tyrosinase); KIS value: 0.177 μmol/L (the inhibition constant of the enzyme-substrate complex) [3]
Target:
In vitro: Mulberroside A decreased the expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and inhibited the activation of NALP3, caspase-1, and nuclear factor-κB and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38 exhibiting anti-inflammatory antiapoptotic effects [1]. Mulberroside A treatment significantly decreased the mRNA and protein expression of P-gp in Caco-2 cells after treatment with Mulberroside A (5–20 μM). PKC and NF-κB might play crucial roles in Mulberroside A-induced suppression of P-gp [2].
In vivo:

  • Spec

Appearance: Powder
Purity: 98.5%

  • References


[1]. Cai-Ping Wang, et al. Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen–glucose deprivation followed by reperfusion. Journal of Neuroscience Research Volume 92, Issue 7, pages 944–954, July 2014
[2]. Yuhua Li, et al. Down-regulation of P-gp expression and function after Mulberroside A treatment: Potential role of protein kinase C and NF-kappa B. Chemico-Biological Interactions Volume 213, 25 April 2014, Pages 44–50
[3]. Shu Wang, et al. An efficient preparation of mulberroside a from the branch bark of mulberry and its effect on the inhibition of tyrosinase activity. PloS one 2014, 9 (10): e109396


price inquiry for CAS:102841-42-9, Product:Mulberroside A