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A-1331852 CAS: 1430844-80-6

Category: Inhibitors
Product Name: A-1331852
Cat No: I000170
CAS No: 1430844-80-6
Synonyms: A-1331852; A 1331852; A1331852.;3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid
Molecular Formula: C38H38N6O3S
Molecular Weight: 658.8
SMILES: O=C(O)C1=NC(N2CCC3=CC=CC(C(NC4=NC5=C(C=CC=C5)S4)=O)=C3C2)=CC=C1C6=C(C)N(CC7(C[C@H]8C9)C[C@H]9C[C@H](C8)C7)N=C6
InChI: InChI=1S/C38H38N6O3S/c1-22-29(19-39-44(22)21-38-16-23-13-24(17-38)15-25(14-23)18-38)27-9-10-33(41-34(27)36(46)47)43-12-11-26-5-4-6-28(30(26)20-43)35(45)42-37-40-31-7-2-3-8-32(31)48-37/h2-10,19,23-25H,11-18,20-21H2,1H3,(H,46,47)(H,40,42,45)
InChIKey: QCQQONWEDCOTBV-JLFAVICQSA-N
Solubility: Soluble in DMSO
Target: Bcl-xL
IC50: Ki: 6 nM for BCL-2 TR-FRET
Storage: Store at -20°C
CAS 1430844-80-6,A-1331852
  • Description

A-1331852(cas 1430844-80-6) is a potent and BCL-XL-selective inhibitor. 

A-1331852 could selectively disrupt BCL-XL–BIM complexes and induce the apoptosis hallmarks in BCL-XL–dependent Molt-4 cells with median IC50 values in the low nanomolar range but did not affect MEF cells without BAK or BAX

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463. Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202. PubMed PMID: 28273655; PubMed Central PMCID: PMC5391241.



price inquiry for CAS:1430844-80-6, Product:A-1331852