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Valbenazine CAS: 1025504-45-3

Category: Inhibitors
Product Name: Valbenazine
Cat No: I000166
CAS No: 1025504-45-3
Molecular Formula: C24H38N2O4
Molecular Weight: 418.57
SMILES: N[C@@H](C(C)C)C(O[C@H]1[C@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@@]2([H])C1)=O
Solubility: 10 mM in DMSO
Target: VMAT2
CAS 1025504-45-3,Valbenazine
  • Description

Valbenazine(cas 1025504-45-3) is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.


It is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines. NBI-98854 is promising agent for the treatment of tardive dyskinesia. NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients. These results support the phase 3 clinical trials of NBI-98854 now underway.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Kim ES. Valbenazine: First Global Approval. Drugs. 2017 Jul;77(10):1123-1129. doi: 10.1007/s40265-017-0770-9. Review. PubMed PMID: 28578484.
2: Valbenazine (Ingrezza) for tardive dyskinesia. Med Lett Drugs Ther. 2017 May 22;59(1521):83-84. PubMed PMID: 28520698.
3: Barquero N. Valbenazine for the treatment of tardive dyskinesia. Drugs Today (Barc). 2016 Dec;52(12):665-672. doi: 10.1358/dot.2016.52.12.2570977. Review. PubMed PMID: 28276538.


price inquiry for CAS:1025504-45-3, Product:Valbenazine