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ZM39923 hydrochloride CAS: 1021868-92-7

Category: Inhibitors
Product Name: ZM39923 hydrochloride
Cat No: I000152
CAS No: 1021868-92-7
Synonyms: 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochloride
Molecular Formula: C23H25NO • HCl
Molecular Weight: 367.9
Solubility: DMSO: ≥ 47 mg/mL
Target: JAK
IC50: 4.4/7.1 (pIC50)
Storage: powder
CAS 1021868-92-7,ZM39923 hydrochloride
  • Description

ZM39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase.
IC50 value: 4.4/7.1 (pIC50)
Target: JAK1/3
in vitro: ZM39923 is a JAK3 inhibitor. ZM39923 is also a potent inhibitor of TGM2 with IC50 of 10 nM. ZM39923 is reversible inhibitors when TGM2 is incubated with inhibitors in the absence of Ca2+. ZM39923 shows significant inhibition of crosslinking activity with IC50 of 25 nM in the absence of DTT and IC50 of 10 μM in the presence of DTT. ZM39923 prevents early death in a Drosophila Melanogaster model of a polyQ repeat disorder called Machado-Joseph Disease. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923 decreases photoaffinity-labeled PS1-CTF in the presense of γ-secretase.

  • Spec

Appearance:A crystalline solid

  • References

price inquiry for CAS:1021868-92-7, Product:ZM39923 hydrochloride