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CARM1-IN-1 CAS: 1020399-49-8

Category: Inhibitors
Product Name: CARM1-IN-1
Cat No: I000146
CAS No: 1020399-49-8
Synonyms: Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
Molecular Formula: C26H21Br2NO3
Molecular Weight: 555.3
SMILES: BrC1=CC(/C=C2CN(CC3=CC=CC=C3)C/C(C\2=O)=C\C4=CC(Br)=C(O)C=C4)=CC=C1O
Solubility: DMSO: ≥ 35 mg/mL
Target: CRAM1
IC50: 8.6 uM
Storage: -20°C
CAS 1020399-49-8,CARM1-IN-1
  • Description

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). 

in vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.

  • Spec

Appearance:A crystalline solid

  • References

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

price inquiry for CAS:1020399-49-8, Product:CARM1-IN-1