Calyculin A

CAS No. : 101932-71-2

Calyculin A,101932-71-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000139
Molecular Formula:C₅₀H₈₁N₄O₁₅P
Molecular Weight:1009.17
Target:Protein Ser/Thr Phosphatases
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Appearance:A solid
Cat No:I000139
Cas No:101932-71-2
Product-Name:Calyculin A
MDL No:MFCD06795864

Calyculin A is a potent inhibitor of the catalytic subunit of type-2A phosphatase, with IC50 values of 0.5 to 1 nM.
Target: protein phosphatase
Calyculin A induces contraction in smooth muscle fibers. With the catalytic subunit of protein phosphatase type-1, calyculin A is an effective inhibitor , IC50 values for calyculin A is about 2 nM and. The endogenous phosphatase of smooth muscle myosin B was inhibited by calyculin A with IC50 values of 0.3 to 0.7 nM for calyculin A. The partially purified catalytic subunit from myosin B had IC50 values of 0.7 nM for calyculin A.

[1]. Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.

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