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Calyculin A CAS: 101932-71-2

Category: Inhibitors
Product Name: Calyculin A
Cat No: I000139
CAS No: 101932-71-2
Synonyms: N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl
Molecular Formula: C50H81N4O15P
Molecular Weight: 1009.2
SMILES: C[C@H]1[C@H](O)C[C@@]2(C(C)(C)[C@@H](OP(O)(O)=O)[C@]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)([H])O2)O[C@H]1C/C=C/C3=COC([C@H](CCNC([C@@H](O)[C@@H](O)[C@@H](N(C)C)COC)=O)C)=N3
Solubility: DMSO: 10 mM
Target: Protein Ser/Thr Phosphatases
Storage: Desiccate at -20°C
CAS 101932-71-2,Calyculin A
  • Description

Calyculin A is a potent inhibitor of the catalytic subunit of type-2A phosphatase, with IC50 values of 0.5 to 1 nM.
Target: protein phosphatase
Calyculin A induces contraction in smooth muscle fibers. With the catalytic subunit of protein phosphatase type-1, calyculin A is an effective inhibitor , IC50 values for calyculin A is about 2 nM and. The endogenous phosphatase of smooth muscle myosin B was inhibited by calyculin A with IC50 values of 0.3 to 0.7 nM for calyculin A. The partially purified catalytic subunit from myosin B had IC50 values of 0.7 nM for calyculin A.

  • Spec

Appearance:A solid

  • References

[1]. Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.

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