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9-Hydroxyellipticin free base CAS: 51131-85-2 (free base)

Category: Inhibitors
Product Name: 9-Hydroxyellipticin free base
Cat No: I000133
CAS No: 51131-85-2 (free base)
Synonyms: 9-hydroxyellipticine; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717; IGIG 929; IGIG929; IGIG-929; LS133324; LS-133324; LS 133324;5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Molecular Formula: C17H14N2O
Molecular Weight: 262.312
SMILES: OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1
InChI: InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3
InChIKey: QZTWUDDGLIDXSE-UHFFFAOYSA-N
Solubility: Soluble in DMSO
Target: None
CAS 51131-85-2 (free base),9-Hydroxyellipticin free base
  • Description

9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


1:Stabilization and Structure of the Cis Tautomer of a Free-Base Porphyrin. Thomas KE, McCormick LJ, Vazquez-Lima H, Ghosh A.Angew Chem Int Ed Engl. 2017 Mar 29. doi: 10.1002/anie.201701965. [Epub ahead of print] PMID: 28370984
2:The application of tailor-made force fields and molecular dynamics for NMR crystallography: a case study of free base cocaine. Li X, Neumann MA, van de Streek J.IUCrJ. 2017 Feb 15;4(Pt 2):175-184. doi: 10.1107/S2052252517001415. eCollection 2017 Mar 1. PMID: 28250956 Free PMC Article
3:Ultrafast Dynamics of Manganese(III), Manganese(II), and Free-Base Bacteriochlorin: Is There Time for Photochemistry? Schaberle FA, Abreu AR, Gonçalves NP, Sá GF, Pereira MM, Arnaut LG.Inorg Chem. 2017 Mar 6;56(5):2677-2689. doi: 10.1021/acs.inorgchem.6b02871. Epub 2017 Feb 16. PMID: 28206747
4:Interaction of free-base tetraphenylporphyrin with magnesium oxide: Influence of MgO morphology on metalation. Di Filippo G, Classen A, Pöschel R, Fauster T.J Chem Phys. 2017 Feb 14;146(6):064702. doi: 10.1063/1.4975229. PMID: 28201886
5:Conductive-probe measurements with nanodots of free-base and metallated porphyrins. Zhai X, Arachchige NM, Derosa P, Garno JC.J Colloid Interface Sci. 2017 Jan 15;486:38-45. doi: 10.1016/j.jcis.2016.09.039. Epub 2016 Sep 17. PMID: 27693519
6:Quantum Dynamics Simulations of Excited State Energy Transfer in a Zinc-Free-Base Porphyrin Dyad. High JS, Rego LG, Jakubikova E.J Phys Chem A. 2016 Oct 7. [Epub ahead of print] PMID: 27661258
7:Demetalation of copper undecaarylcorroles: Molecular structures of a free-base undecaarylisocorrole and a gold undecaarylcorrole. Capar J, Zonneveld J, Berg S, Isaksson J, Gagnon KJ, Thomas KE, Ghosh A.J Inorg Biochem. 2016 Sep;162:146-153. doi: 10.1016/j.jinorgbio.2016.06.026. Epub 2016 Jun 27. No abstract available. PMID: 27394061
8:Synthesis of Free-Base 10-Azacorroles. Omori H, Hiroto S, Shinokubo H.Org Lett. 2016 Jun 17;18(12):2978-81. doi: 10.1021/acs.orglett.6b01323. Epub 2016 Jun 3. PMID: 27258675
9:Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients. Hoppentocht M, Akkerman OW, Hagedoorn P, Alffenaar JW, van der Werf TS, Kerstjens HA, Frijlink HW, de Boer AH.PLoS One. 2016 Mar 9;11(3):e0149768. doi: 10.1371/journal.pone.0149768. eCollection 2016. PMID: 26959239 Free PMC Article
10:Interfacial charge rearrangement and intermolecular interactions: Density-functional theory study of free-base porphine adsorbed on Ag(111) and Cu(111). Müller M, Diller K, Maurer RJ, Reuter K.J Chem Phys. 2016 Jan 14;144(2):024701. doi: 10.1063/1.4938259. PMID: 26772581


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