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LPA2 antagonist 1 CAS: 1017606-66-4

Category: Inhibitors
Product Name: LPA2 antagonist 1
Cat No: I000131
CAS No: 1017606-66-4
Synonyms: (S)-N-(1-(4-((3,4-dichlorophenyl)sulfonyl)piperazin-1-yl)propan-2-yl)-7-methylthieno[3,2-d]pyrimidin-4-amine
Molecular Formula: C20H23Cl2N5O2S2
Molecular Weight: 500.5
SMILES: ClC1=CC=C(S(N2CCN(C[C@H](C)NC3=NC=NC4=C3SC=C4C)CC2)(=O)=O)C=C1Cl
InChI: InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1
InChIKey: BPRNMVDTWIHULJ-AWEZNQCLSA-N
Solubility: 10 mM in DMSO
Target: LPL Receptor
IC50: > 30 uM [1]
Storage: Store at -20°C
CAS 1017606-66-4,LPA2 antagonist 1
  • Description

LPA2 antagonist1 is a selective inhibitor of LPA2 activity in with IC50 17 nM in vitro for inhibition of LPA(2) mediated Erk activation and proliferation of HCT-116 cells.
IC50 value: > 30 uM [1]
Target: LPA2

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.
[2]. Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5239-43.


price inquiry for CAS:1017606-66-4, Product:LPA2 antagonist 1