Tenovin 6 Hydrochloride

CAS No. : 1011301-29-3

Tenovin 6 Hydrochloride,1011301-29-3
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000116
Molecular Formula:C25H35ClN4O2S
Molecular Weight:491.09
Target:SIRT1; SIRT2
IC50:21 uM (human SIRT1); 10 uM (human SIRT2) [1]
Price:Get quote
We match the lowest price on market.

Your information is safe with us.

Cat No:I000116
Cas No:1011301-29-3
Product-Name:Tenovin 6 Hydrochloride

Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.
IC50 value: 21 uM (human SIRT1); 10 uM (human SIRT2) [1]
Target: SIRT1; SIRT2
in vitro: Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1. Tenovin-6 decreases purified human SirT1 peptide deacetylase activity in vitro with an IC50 of 21 μM and human SirT2 activity with an IC50 of 10 μM. Inhibition of SirT3 by tenovin-6 in this assay was significantly lower with an IC50 of 67 μM.Tenovin-6 does not inhibit enzymatic assays in general as the activity of a panel of 51 purified kinases was not significantly affected [1]. KIAA1967 expression is differentially downregulated in PDAC and impacts on the sensitivity of PDAC cells to the Sirt1/2 inhibitor Tenovin-6 [2]. In chronic lymphocytic leukemia (CLL) cells, Tnv-6 causes non-genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity [3].
in vivo: Tenovin-6 was administered daily at 50 mg/kg by intraperitoneal injection. Control animals were treated with vehicle solution containing cyclodextrin 20% (w/v) (Cat. No. C0926 Sigma) and DMSO 10% (v/v). Tumor diameters were measured using calipers, and volumes were calculated using the equation V = π4/3[(d1 + d2)/4]. Median values of tumor size were calculated for each time point as well as the corresponding 95% confidence intervals [1].

[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.
[2]. Wauters E, et al. Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res. 2013 Apr 1;73(7):2357-67.
[3]. MacCallum SF, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275.

Recommended Products
  • CAS No. :172544-75-1
    Product Name:

    KY 234

    Cat No: M037230 View details
  • CAS No. :164077-49-0
    Product Name:


    Cat No: M037231 View details
  • CAS No. :169888-58-8
    Product Name:

    [1,2,3]Triazolo[1,5-a]pyridine-7-carboxaldehyde (9CI)

    Cat No: M037232 View details
  • CAS No. :180186-94-1
    Product Name:


    Cat No: M037233 View details