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Tenovin-3 CAS: 1011301-27-1

Category: Inhibitors
Product Name: Tenovin-3
Cat No: I000115
CAS No: 1011301-27-1
Synonyms: Tenovin 3
Molecular Formula: C18H21N3OS
Molecular Weight: 327.4
SMILES: CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(N)C=C2)=S)=O)C=C1
InChI: InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23)
InChIKey: NLAXTZPUTNGRDU-UHFFFAOYSA-N
Solubility: DMSO: > 31 mg/mL
Target: p53
Storage: Store at -20°C
CAS 1011301-27-1,Tenovin-3
  • Description

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM. 

in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.


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