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Piceatannol CAS: 10083-24-6

Category: Inhibitors
Product Name: Piceatannol
Cat No: I000099
CAS No: 10083-24-6
Synonyms: 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
Molecular Formula: C14H12O4
Molecular Weight: 244.2
SMILES: Oc1cc(\C=C/c2ccc(O)c(O)c2)cc(O)c1
Solubility: Soluble in DMSO to 100 mM and in ethanol to 100 mM
Target: IκB/IKK
Storage: powder
CAS 10083-24-6,Piceatannol
  • Description

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

  • Spec

Appearance: Powder
Purity: 98.5%

  • References

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.
[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

price inquiry for CAS:10083-24-6, Product:Piceatannol