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MK-2894 sodium salt CAS: 1006036-88-9

Category: Inhibitors
Product Name: MK-2894 sodium salt
Cat No: I000094
CAS No: 1006036-88-9
Synonyms: sodium 4-(1-(2,5-dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxamido)cyclopropyl)benzoate
Molecular Formula: C25H21F3NNaO3S
Molecular Weight: 495.49
SMILES: CC1=C(CC2=CC=C(C(F)(F)F)C=C2)C(C(NC3(C4=CC=C(C([O-])=O)C=C4)CC3)=O)=C(C)S1.[Na+]
Solubility: 10 mM in DMSO
Target: EP4 Receptor
Storage: Store at -20°C
CAS 1006036-88-9,MK-2894 sodium salt
  • Description

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.
IC50 value:
Target: EP4
MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

  • References


[1]. Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, Lévesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O'Neill G, Ducharme Y, Friesen R. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem. 2010 Mar 11;53(5):2227-38. Abstract The discovery of highly potent and selective second generation EP(4) antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.


price inquiry for CAS:1006036-88-9, Product:MK-2894 sodium salt