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MX69 CAS: 1005264-47-0

Category: Inhibitors
Product Name: MX69
Cat No: I000088
CAS No: 1005264-47-0
Molecular Formula: C27H26N2O4S
Molecular Weight: 474.57
SMILES: O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O
InChI: InChI=1S/C27H26N2O4S/c1-16-5-3-8-24(17(16)2)29-34(32,33)20-13-14-25-23(15-20)21-6-4-7-22(21)26(28-25)18-9-11-19(12-10-18)27(30)31/h3-6,8-15,21-22,26,28-29H,7H2,1-2H3,(H,30,31)
InChIKey: LAISWEODQAOXGJ-UHFFFAOYSA-N
Solubility: DMSO: ≥ 30 mg/mL
Target: None
CAS 1005264-47-0,MX69
  • Description

MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro and inhibition of cancer cell proliferation in vivo.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References


[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636.


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