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TZ9 CAS: 1002789-86-7

Category: Inhibitors
Product Name: TZ9
Cat No: I000078
CAS No: 1002789-86-7
Synonyms: (4-amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate
Molecular Formula: C17H14N6O4
Molecular Weight: 366.3
SMILES: NC1=NC(COC(C2=CC=C([N+]([O-])=O)C=C2)=O)=NC(NC3=CC=CC=C3)=N1
Solubility: DMSO: ≥ 40 mg/mL
Target: DUB
IC50: 6 uM [1]
Storage: Store at -20°C
CAS 1002789-86-7,TZ9
  • Description

TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.
IC50 value: 6 uM [1]
Target: Rad6 inhibitor
The bulk of MDA-MB-231 cells treated with 10 μmol/L or more SMI #9 displayed a round morphology compared with controls and less than 5 μmol/L doses of SMI #9. Simultaneous comparison of SMIs #8 and 9 confirmed SMI #9 inhibits Matrigel-induced migration of MDA-MB-231 cells in a dose-dependent manner compared with SMI #8. 5 μmol/L SMI #9 treatment triggered morphologic changes consistent with apoptosis in a time-dependent manner. 5 μmol/L SMI #9 treatment of MDA-MB-231 cells for 24 hours increased the proportion of G2–M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells. SMIs #8 or 9 treatments dramatically reduced β-catenin staining as visualized by reduced merged Rad6/β-catenin yellow fluorescence.

  • Spec

Appearance:A crystalline solid

  • References

[1]. Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013 Apr;12(4):373-83.

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