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SRT 1720 Hydrochloride CAS: 1001645-58-4

Category: Inhibitors
Product Name: SRT 1720 Hydrochloride
Cat No: I000075
CAS No: 1001645-58-4
Synonyms: N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride
Molecular Formula: C25H23N7OS • XHCl
Molecular Weight: 506.0
Solubility: DMSO: 38 mg/mL, H2O: <1 mg/mL
Target: Sirtuin
IC50: 0.16 μM(EC1.5 for SIRT1)
Storage: powder
CAS 1001645-58-4,SRT 1720 Hydrochloride
  • Description

SRT1720 hydrochloride is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).
IC50 Value: 0.16 μM(EC1.5 for SIRT1)
Target: SIRT1
SRT 1720 binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, SRT1720 improved insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. Thus, SRT1720 is a promising new therapeutic agent for treating diseases of ageing such as type 2 diabetes.

  • Spec

Appearance:A crystalline solid

  • References

[1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6
[2]. Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R.,Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61
[3]. Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, R?nty M, Kinnula VL, Rahman I.,SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45.
[4]. Villalba JM, Alcaín FJ.,Sirtuin activators and inhibitors.,Biofactors. 2012 Jun 25.
[5]. Jang SY, Kang HT, Hwang ES.,Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation.,J Biol Chem. 2012 Jun 1;287(23):19304-14. Epub 2012 Apr 9.

price inquiry for CAS:1001645-58-4, Product:SRT 1720 Hydrochloride