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NSC 405020 CAS: 7497-07-6

Category: Inhibitors
Product Name: NSC 405020
Cat No: I000060
CAS No: 7497-07-6
Synonyms: 3,4-dichloro-N-pentan-2-ylbenzamide
Molecular Formula: C12H15Cl2NO
Molecular Weight: 260.2
InChI: InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
Solubility: 10 mM in DMSO
Target: MMP
IC50: > 100 uM [1]
Storage: Store at RT
CAS 7497-07-6,NSC 405020
  • Description

NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.
IC50 value: > 100 uM [1]
Target: MT1-MMP PEX inhibitor
NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

[1]. Remacle AG, et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012 May 1;72(9):2339-49.

price inquiry for CAS:7497-07-6, Product:NSC 405020