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1400W HCl CAS: 214358-33-5

Category: Inhibitors
Product Name: 1400W HCl
Cat No: I000050
CAS No: 214358-33-5
Synonyms: 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride).;N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride
Molecular Formula: C10H17Cl2N3
Molecular Weight: 250.167
SMILES: CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
InChI: InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChIKey: WDJHSQZCZGPGAA-UHFFFAOYSA-N
Solubility: Soluble in DMSO
CAS 214358-33-5,1400W HCl
  • Description

1400W is a highly selective inducible nitric oxide synthase inhibitor and is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. 1400W blocks death pathway of LPS-induced activated-microglia to preOLs.

  • Spec

Appearance:Solid powder
Purity: > 98%

  • References

1: Al-Akl NS, Ismail M, Khaliefeh F, Usta J, Abdelnoor AM. Effects of catalase and 1400W on the number of interleukin-4 and interferon-γ secreting spleen cells in mice injected with ovalbumin and alum. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):951-5. doi: 10.3109/08923973.2012.674530. Epub 2012 May 3. PubMed PMID: 22551050.
2: Hosgood SA, Yates PJ, Nicholson ML. 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor. World J Transplant. 2014 Dec 24;4(4):299-305. doi: 10.5500/wjt.v4.i4.299. PubMed PMID: 25540738; PubMed Central PMCID: PMC4274599.
3: Ozturk M, Ozler M, Kurt YG, Ozturk B, Uysal B, Ersoz N, Yasar M, Demirbas S, Kurt B, Acikel C, Oztas Y, Arpaci F, Topal T, Ozet A, Ataergin S, Kuzhan O, Oter S, Korkmaz A. Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity. J Pineal Res. 2011 Jan;50(1):89-96. doi: 10.1111/j.1600-079X.2010.00818.x. Epub 2010 Nov 9. PubMed PMID: 21062350.
4: Puttachary S, Sharma S, Verma S, Yang Y, Putra M, Thippeswamy A, Luo D, Thippeswamy T. 1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. Neurobiol Dis. 2016 Sep;93:184-200. doi: 10.1016/j.nbd.2016.05.013. Epub 2016 May 18. PubMed PMID: 27208748.
5: He YF, Chen HJ, Qian LH, Chen GY. Effect of 1400W on blocking lipopolysaccharide-induced microglial toxicity to preoligodendrocytes. World J Pediatr. 2010 Aug;6(3):249-54. doi: 10.1007/s12519-010-0203-2. Epub 2010 Jun 12. PubMed PMID: 20549418.
6: Poyrazoglu Y, Yigit T, Harlak A, Mentes O, Gorgulu S, Uzar AI, Kozak O. Effects of prevention of oxidative and nitro-oxidative stress on experimental rat colon anastomosis using acetylcysteine, Ebselen and 1400w. Acta Chir Belg. 2011 Jan-Feb;111(1):26-31. PubMed PMID: 21520784.
7: Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63. PubMed PMID: 9030556.
8: He YF, Chen HJ, Qian LH, Chen GY. [1400W blocks death pathway of LPS-induced activated-microglia to preOLs]. Zhongguo Dang Dai Er Ke Za Zhi. 2010 May;12(5):357-62. Chinese. PubMed PMID: 20497644.


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