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Pristinamycin IA CAS: 3131-03-1

Category: Inhibitors
Product Name: Pristinamycin IA
Cat No: I000037
CAS No: 3131-03-1
Molecular Formula: C45H54N8O10
Molecular Weight: 867
Solubility: DMSO ≥ 28 mg/mL
CAS 3131-03-1,Pristinamycin IA
  • Description

Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.
In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]

  • Spec

Appearance:White solid

  • References

[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

price inquiry for CAS:3131-03-1, Product:Pristinamycin IA