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CORM-3 CAS: 475473-26-8

Category: Inhibitors
Product Name: CORM-3
Cat No: I000012
CAS No: 475473-26-8
Synonyms: Carbon monoxide releasing molecule 3; Tricarbonylchloro(glycinato)ruthenium (II)
Molecular Formula: C5H4ClNO5Ru
Molecular Weight: 294.61
SMILES: O=C1[O-][Ru+2]([Cl-])([C]=O)([C]=O)([C]=O)[NH2]C1
Solubility: Soluble in DMSO > 10 mM
Storage: Store at -20°C
CAS 475473-26-8,CORM-3
  • Description

CORM-3(cas 475473-26-8) is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

  • References

1: Yan BZ, Yang BS, Li H, Zhang YF, Pei FH, Zhu AC, Wang XR, Liu BR. The therapeutic effect of CORM-3 on acute liver failure induced by lipopolysaccharide/D-galactosamine in mice. Hepatobiliary Pancreat Dis Int. 2016 Feb;15(1):73-80. PubMed PMID: 26818546.
2: Wilson JL, McLean S, Begg R, Sanguinetti G, Poole RK. Analysis of transcript changes in a heme-deficient mutant of Escherichia coli in response to CORM-3 [Ru(CO)(3)Cl(glycinate)]. Genom Data. 2015 Jun 13;5:231-234. eCollection 2015 Sep. PubMed PMID: 26322270; PubMed Central PMCID: PMC4543538.
3: Wilson JL, Wareham LK, McLean S, Begg R, Greaves S, Mann BE, Sanguinetti G, Poole RK. CO-Releasing Molecules Have Nonheme Targets in Bacteria: Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3 [Ru(CO)3Cl(glycinate)] Actions on a Heme-Deficient Mutant of Escherichia coli. Antioxid Redox Signal. 2015 Jul 10;23(2):148-62. doi: 10.1089/ars.2014.6151. Epub 2015 Apr 28. PubMed PMID: 25811604; PubMed Central PMCID: PMC4492677.
4: Tinajero-Trejo M, Denby KJ, Sedelnikova SE, Hassoubah SA, Mann BE, Poole RK. Carbon monoxide-releasing molecule-3 (CORM-3; Ru(CO)3Cl(glycinate)) as a tool to study the concerted effects of carbon monoxide and nitric oxide on bacterial flavohemoglobin Hmp: applications and pitfalls. J Biol Chem. 2014 Oct 24;289(43):29471-82. doi: 10.1074/jbc.M114.573444. Epub 2014 Sep 5. PubMed PMID: 25193663; PubMed Central PMCID: PMC4207967.
5: Rana N, McLean S, Mann BE, Poole RK. Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry. Microbiology. 2014 Dec;160(Pt 12):2771-9. doi: 10.1099/mic.0.081042-0. Epub 2014 Aug 1. PubMed PMID: 25085864.
6: Nielsen VG, Garza JI. Comparison of the effects of CORM-2, CORM-3 and CORM-A1 on coagulation in human plasma. Blood Coagul Fibrinolysis. 2014 Dec;25(8):801-5. doi: 10.1097/MBC.0000000000000146. PubMed PMID: 25058038.
7: Long R, Salouage I, Berdeaux A, Motterlini R, Morin D. CORM-3, a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier. Biochim Biophys Acta. 2014 Jan;1837(1):201-9. doi: 10.1016/j.bbabio.2013.10.002. Epub 2013 Oct 23. PubMed PMID: 24161358.

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