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Avibactam Sodium CAS: 1192491-61-4

Category: Inhibitors
Product Name: Avibactam Sodium
Cat No: I000003
CAS No: 1192491-61-4
Synonyms: Avibactam Sodium Salt;Sulfuric Acid Mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] Ester Sodium Salt; NXL 104;
Molecular Formula: C7H10N3O6S • Na
Molecular Weight: 287.2
SMILES: NC([C@H]1[N@@](C2)C(N(OS([O-])(=O)=O)[C@@H]2CC1)=O)=O.[Na+]
InChIKey: RTCIKUMODPANKX-JBUOLDKXSA-M
Solubility: 10 mM in H2O, DMSO: ≥ 30 mg/mL
Target: β-lactamase
Storage: -20°C
CAS 1192491-61-4 ,Avibactam Sodium
  • Description

Purity:  HPLC>=98%

Quantity: Miligrams-Grams
Usage: For research use only.


Avibactam is a non-β-lactam β-lactamase inhibitor antibiotic, which is a new drug application for avibactam in combination with ceftazidime, and was approved by the FDA on February 25, 2015, for treating complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant gram-negative bacterial pathogens.

  • Spec

None

  • References

[1]. In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae By Aktas, Z.; Kayacan, C.; Oncul, O. From International Journal of Antimicrobial Agents (2012) 

[2]. Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

[3]. Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN. Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, including Strains Expressing One or More β-Lactamases and Methicillin-Resistant Staphylococcus aureus Carrying Various Staphylococcal Cassette Chromosome mec Types. Antimicrob Agents Chemother. 2012 Sep;56(9):4779-85. 

[4]. Livermore DM, Mushtaq S, Barker K, Hope R, Warner M, Woodford N. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8.


price inquiry for CAS:1192491-61-4 , Product:Avibactam Sodium